WDEL Blog: Allan Loudell

If you or a family member is taking meds, and enjoys Grapefruit, read this: It could save your life!

I've been saving this medical item for the end of the week.

A frightening escalating number of prescription medications have been shown to interact with grapefruit and grapefruit juices (Also Seville oranges, but NOT regular oranges & orange juice).

You risk gastrointestinal bleeding; kidney failure; shallow breathing; and/or sudden death.

As pharmaceuticals rapidly come onto the market, these interactions are not necessarily flagged immediately. Even physicians and pharmacists may not immediately become aware of the risks. (We've known for two decades about grapefruit's interactions with pharmaceuticals, but the list of affected prescription drugs is expanding exponentially.)

It's not that the furanocoumarins found in grapefruit block a prescription drug's effects. Rather, these chemicals neutralize an enzyme in the gut which normally slows the body's absorption of the active ingredients in a prescription drug. So you get overdosed.

If you or a family member consumes grapefruit or grapefruit juice - and takes prescription medication - you need to read this account from Canada's GLOBE & MAIL. Some of the drugs that don't mix with grapefruit are listed here. But, if not, I'd still urge you to be pro-active: Press your doctor and pharmacist; do independent research. (Unless it's absolutely your favorite fruit, one starts to think grapefruit ain't worth it!)


You can hear my interview with pharmacologist Dr. David Bailey at the Lawson Health Research Institute in London, Ontario, Canada, the researcher who first noted harmful grapefruit interactions with some meds about two decades ago...

Audio Here

Posted at 6:33am on November 30, 2012 by Allan Loudell

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Comments on this post:

Mike from Delaware
Fri, Nov 30, 2012 9:42pm
Allan: Thanks for the link, I had never heard of this. I also found here an article online about this on Forbes. I'm passing on both articles on to my elderly parents as this might be important info. Again, Thank you.


Sun, Dec 2, 2012 10:21pm
I take the blood pressure drug lisinopril. I did some research and there seem to be mixed opinions about interaction with grapefruit. Seems to affect some people and not others. In any case, I will skip my dosage if I decide to eat a grapefruit. Thanks for the info, Allan.

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