The Yankees overcame Chris Davis' major league-leading 33rd home run and yet another double from Manny Machado, celebrating his 21st birthday. The Orioles have lost four of five.
The 41-year-old Pettitte (6-6) earned his 251st win, tying Hall of Famer Bob Gibson for 44th place on the all-time list.
Pettitte persevered on a hot, sticky day, hanging in after the Orioles took an early 3-0 lead. He got a big cheer when he trotted off with two outs in the seventh inning after exactly 100 pitches, and ended a four-start winless string.
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