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Photo courtesy nbc10.com

More than 100 people were hospitalized in the Philadelphia area over the weekend due to a bad batch of drugs, according to health officials.

Officials said Philadelphia area hospitals saw a sudden spike in nonfatal drug overdoses between Friday and Saturday. Philadelphia Health Commissioner Tom Farley said the cluster was the largest he has seen in two years as head of the city's health department. 

“Over a weekend we might expect 20 to 25 people to come in,” Dr. Farley said. “So to have 100 come in is a lot larger than normal.”

Farley says it's unclear whether the substance responsible was heroin, fentanyl or something else. Health officials are still waiting for results of tests of bags found in the hands of arriving patients.

Montgomery County officials said the drug may be “Santa Muerte," meaning “The Holy Death,” a batch of heroin adulterated with an anticholinergic agent. Sold on the street with the name “Perfect 10,” symptoms of the batch include agitation, combativeness, delirium, dilated pupils, seizures and hot, flushed and red skin.

Officials warned first responders that patients overdosed on Santa Muerte are typically extremely combative and agitated when being treated with the anti-opiate drug Narcan.

At least two female Philadelphia EMS workers who responded to reported overdoses Friday were hurt after being attacked by patients, according to officials. 

“This is an important lesson for everyone on how dangerous it is to buy drugs on the street and use them,” Dr. Farley said.

Despite the rise in overdoses, officials said the batch didn't caused a spike in drug-related deaths over the weekend. 

Police and the health department are currently warning people about the issue as they continue to work to confirm what the drug actually is. They expect to complete their testing this week.